The study titled, Impact of mRNA and Inactivated COVID-19 Vaccines on Ovarian Reserve, was recently published in the journal Vaccines:
Objectives: This study aimed to elucidate the effects of messenger RNA (mRNA) and inactivated coronavirus disease 2019 (COVID-19) vaccines on ovarian histology and reserve in rats.
Methods: Thirty female Wistar albino rats, aged 16–24 weeks, were randomly divided into three groups (n = 10): control, mRNA vaccine, and inactivated vaccine groups. Each vaccine group received two doses (on day 0 and day 28) at human-equivalent doses. Four weeks post-second vaccination, ovarian tissues were harvested for analysis.
Results: Immunohistochemical analysis was performed to evaluate the expression of transforming growth factor beta-1 (TGF-β1), vascular endothelial growth factor (VEGF), caspase-3, and anti-Müllerian hormone (AMH) in ovarian follicles. Both vaccines induced significant increases in TGF-β1, VEGF, and caspase-3 expression, with more pronounced effects in the mRNA vaccine group. Conversely, AMH expression in the granulosa cells of primary, secondary, and antral follicles showed marked reductions (p < 0.001). The counts of primordial, primary, and secondary follicles decreased significantly in the inactivated vaccine group relative to controls and further in the mRNA vaccine group compared to the inactivated group (p < 0.001). Additionally, the mRNA vaccine group exhibited a decrease in antral and preovulatory follicles and an increase in atretic follicles compared to the other groups (p < 0.05). The serum AMH level was diminished with the mRNA vaccination in comparison with the control and inactivated groups.
Conclusions: Our findings suggest that both mRNA and inactivated COVID-19 vaccines may detrimentally impact ovarian reserve in rats, primarily through accelerated follicular loss and alterations in apoptotic pathways during folliculogenesis. Given these observations in a rat model, further investigations into the vaccines’ effects on human ovarian reserve are needed.
Here’s what the study found in simple terms:
Severe Destruction of Ovarian Reserve
Rats injected intramuscularly with a Pfizer-BioNTech COVID-19 mRNA vaccine — at a human-equivalent dose — experienced a >60% reduction in primordial follicles, the foundational egg supply for future fertility (p < 0.001).
The inactivated vaccine (CoronaVac) also caused loss, but to a lesser extent.
Damage Targets Non-Renewable Egg Supply
The primordial follicle pool is finite and non-regenerating — females are born with all the eggs they will ever have.
Destruction of this pool is irreversible, leading to permanent fertility loss if translated to humans.
Anti-Müllerian Hormone (AMH) Levels Crashed
AMH, a hormone reflecting ovarian reserve, dropped significantly in the mRNA group — both in serum and in ovarian tissue (p < 0.001).
Lower AMH is associated with poor fertility outcomes and earlier menopause.
Elevated Cell Death and Inflammatory Signals
Increased expression of caspase-3 (a cell-death enzyme) and inflammatory markers like TGF-β1 and VEGF were found in vaccinated rats.
These biomarkers are linked to ovarian atresia, fibrosis, and long-term tissue damage.
More Severe Effects with mRNA Vaccines
Compared to the inactivated vaccine, the mRNA group had:
Fewer growing follicles (primary, secondary, antral, preovulatory)
More dying follicles (atretic)
Greater reductions in hormone markers of fertility
If these findings indeed apply to humans, the implications for global fertility rates are profound. This kind of damage — to a woman’s lifelong egg supply — is biologically irreversible.
Unfortunately, a recent study by Manniche et al indicates that these ovarian reserve destruction findings likely DO translate to humans. Among ~1.3 million Czech women aged 18–39, those vaccinated against COVID-19 had ~33% fewer successful pregnancies compared to unvaccinated women:
NEW STUDY — Mass mRNA Injection Campaigns Likely Fueling the Global Fertility Collapse
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Ovarian damage likely occurs because the lipid nanoparticles encapsulating the mRNA have a particular preference for the ovaries, according to an Australian TGA report:
These data indicate that our public health agencies, in compliance with the Bio-Pharmaceutical Complex, have compromised the capacity to create new life across the world — by destroying ovarian reserves. And they’re still doing it.
Epidemiologist and Foundation Administrator, McCullough Foundation
www.mcculloughfnd.org
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